The IEEE Workshop on Signal and Power Integrity (SPI) is an annual scientific event dedicated to all aspects of Signal and Power Integrity, comprising the latest research and developments on design, characterization, modeling, simulation and testing at chip, package, board, and system level. Aiming to bring together developers and researchers from academia and industry in order to encourage cooperation, the workshop's technical program will include both oral and poster sessions, while several prominent experts will be giving keynotes and tutorials on areas of emerging interest. SPI 2025 will be held as an in-person event during May 11-14, 2025, in Gaeta, Italy.